Taking Duphaston during pregnancy - how much can you take, will there be side effects?

Duphaston as a medicine

Duphaston is a drug that plays an important role in conceiving a baby, as well as in maintaining pregnancy, especially in the early stages of its development, for expectant mothers with low levels of the hormone progesterone.

The value of this drug lies in the fact that its main active ingredient is dihydrogesterone - an artificially created synthetic hormone progesterone. But this fact does not in any way reduce its effectiveness, since in its properties it is as close as possible to natural progesterone.

The use of Duphaston is possible only as prescribed by a doctor.

Duphaston is an imported medicine produced by a pharmaceutical company in the Netherlands. The cost of this drug in Moscow and the Moscow region ranges from 550–790 Russian rubles for 20 or 28 pieces per package.

Duphaston is produced in the form of white biconvex tablets for oral use, each of which contains 10 mg of the active substance. This drug is released from pharmacy shelves only with a doctor's prescription.

The role of Duphaston when planning pregnancy

For many women, it is no secret that conceiving and bearing a baby is impossible without the main pregnancy hormone, which not only creates favorable conditions for fertilization of the egg, but also prepares the walls of the uterus for the attachment of the fertilized egg to it. Moreover, progesterone relaxes the smooth muscles of the internal organs of the expectant mother, which helps prevent uterine hypertonicity.

Unfortunately, not all loving couples manage to conceive a baby easily; sometimes it takes many years. When contacting a gynecologist with this problem, the first thing the doctor will prescribe is a blood test to determine the level of progesterone, which is usually done on the 15th–26th day of the cycle.

In the case of a normal pregnancy, there is no need to monitor the level of progesterone in the blood

When planning conception, Duphaston replenishes the lack of progesterone in a woman’s body, which has a beneficial effect on all processes occurring in the reproductive system during the period of fertilization and fetal development.

A deficiency of progesterone in the blood does not always cause infertility. Sometimes this can be facilitated by infectious and inflammatory diseases of the reproductive system. Therefore, it is very important to undergo a full examination to identify the problem before prescribing medications.

An analysis of progesterone levels is not mandatory for all women planning a pregnancy, as well as pregnant women. It is done only for medical reasons. Personally, I didn’t have any problems during the pregnancy planning stage, but progesterone deficiency appeared in the first trimester of gestation. This was discovered during registration in the 8th week, when, after examination on the chair, the gynecologist noticed a large number of deviations from the norm, which means there was a high risk of spontaneous miscarriage. In this regard, the specialist prescribed me an impressive number of tests, including a blood test for progesterone. The results were ready the next day after the biomaterial was submitted. Since the analysis showed low progesterone levels, I was admitted to the gynecology department for conservation, where, in addition to other medications, I took Duphaston in the morning and evening, one tablet. I took this drug until the 14th week of pregnancy, even after being discharged from the hospital. At the same time, closer to the 10th week, the doctor began to gradually reduce the dosage of Duphaston.

Duphaston and pregnancy. Patient's story

My story began at the age of 14. I started getting my period, and like many girls, it was irregular at first.

After 2 years, the situation has not changed - they came either 2 times a month, or they might not come for 3 months in a row.

Then my mother took me to a gynecologist, they told me that I had polycystic ovary syndrome and sent me to a brain research center. They stuck a bunch of sensors to my head and started measuring brain activity on a computer.

An hour later I was diagnosed with incorrect functioning of the pituitary gland, which is responsible for the menstrual cycle.

They told me that it would be very difficult for me to get pregnant, and they prescribed a lot of pills, they had to be taken strictly by the hour, in order, for a course of 3 months.

After 3 weeks, I began to experience strange side effects that we were not warned about and that should not have happened - I began to cry for any reason, throw hysterics out of nowhere.

Mom threw away the pills, we didn’t go to the brain research center anymore...

Then, to normalize the menstrual cycle, I was prescribed Remens and other pills, but none of them gave the desired effect. And at the age of 19, I started taking oral contraceptives and took them for 8 years, my periods came exactly on the clock.

At the age of 27, I got married, and we realized that we wanted a child.

We decided to undergo a full medical examination. At the gynecologist’s appointment, as always, I told my story, brought all the papers... they looked at me in the chair, did an ultrasound. and I heard the same phrase: “you know, you most likely have polycystic disease. you will have to try very hard to get pregnant!” I never went to this gynecologist again.

I found a good doctor who monitored the pregnancies of three of my friends from start to finish. all three are mothers of pretty children. and I felt that I could finally trust the doctor and they would help me.

At the initial appointment, the doctor listened to my story, looked at me in the chair and on the ultrasound. and I didn’t hear that terrible phrase that everyone used to scare me.

The doctor canceled ok and prescribed duphaston - from 16 to 25 days of the cycle.

Duphaston was supposed to help me get pregnant. and we agreed that I would come on certain days of the cycle, and she would look at me with an ultrasound for the formation of dominant follicles and ovulation. so we did.

the first study consisted of 3 ultrasounds on different days of the cycle, but I did not ovulate. nor were there any dominant follicles.

After carefully studying the ultrasound images and consulting with a colleague, the doctor diagnosed me with multifollicular ovaries.

They explained to me that this is a milder version of polycystic disease, and that not everything is so scary. and, probably, this cycle for me simply can be anovulatory, that is, without ovulation. This is within the normal range for women: 1-2 cycles per year

“Continue to drink Duphaston from days 16 to 25, and come back in the next cycle, we will repeat the study.”

Well, my husband was advised to take a spermogram.

I bought a whole package of test strips for ovulation and pregnancy. I took ovulation tests almost every day, but I always saw one line. The spermogram results came back good. We repeated the series of ultrasounds. And again there was no ovulation.

At my last ultrasound, they discovered a small polyp that was located in the uterus in such a way that it could hypothetically interfere with the passage of sperm and fertilization of the egg.

The doctor referred me to her friend at the hospital for surgery. The operation was successful, they cauterized the polyp, and a week later a repeat ultrasound confirmed that everything had healed perfectly.

You cannot be sexually active for three months and continue taking Duphaston.

I was just getting ready to go on vacation, and after the vacation I came back to see my doctor. During the ultrasound I burst into tears because we still couldn’t find ovulation. It turns out that I am not capable of having children at all. In a kind of fog, I listened to the doctor - about her plans to give me intravenous injections to stimulate ovulation, about painful checks for the patency of the tubes, about some kind of operation...

I left the office and got into the car. I was in such despair that I couldn’t calm down for a long time. I pulled myself together and went home. they were all right, I couldn't have children. Every time my period was late, I took pregnancy tests, but the second line never appeared.

Automatically, I continued to take Duphaston until I stopped drinking it in February 2017. I started taking folic acid, which was recommended for everyone planning a pregnancy. We decided that we would not go to the doctors anymore for now and would leave the topic of children.

Naturally, after some time I began to forget to drink folic acid every day, I drank it when I remembered. Several times I literally lost my mind after meeting our friends with children. I couldn't look at them without tears in my eyes. But that too passed.

In August we went to the seaside for three months, drank wine, smoked cigars, and swam.

A couple of times my husband raised the topic of children, saying that if it doesn’t work out in the near future, then when we get home we should check my pipes. At that moment, I remember, I almost fainted from the mere thought that I would again have to run to doctors, have operations, that I would again sit in this terrible chair.

3 weeks before leaving home, I felt bad - I started getting motion sickness in the car, which had never happened before, I ate with force, and I periodically felt nauseous, my chest and lower abdomen hurt. “Period... Just in time!” - we thought.

But my period did not come in a day or a week. When I almost fainted in the store, my husband forced me to buy a pregnancy test.

Of course, I refused, saying that it was pointless, and I would only cry again, seeing this one stripe.

The next morning I took a test. And for the first time in my life I saw two fat stripes. I ran out of the bathroom like a whirlwind and started crying like a little child.

My husband jumped on the bed and began to read the instructions to see if I had done everything correctly. The next morning I did the test again, and again there were two greasy lines...

Upon arrival in Moscow, we immediately made an appointment with a well-known gynecologist, about whom trusted sources of evidence-based medicine wrote. They looked at me on an ultrasound and did not see any polycystic disease. Pregnancy confirmed.

I again told my whole story from the very beginning, and our surprise knew no bounds when they explained to us, almost on the graph of my menstrual cycle, why we could not get pregnant all this time on Duphaston.

The fact is that a woman’s standard menstrual cycle lasts 28 days, and ovulation occurs on days 14-15. Duphaston is taken from days 16 to 25, after ovulation.

But my cycle is not 28 days, it is unstable and ranges from 25 to 75 days, which is not the norm.

Accordingly, my ovulation does not occur on the 15th day, but occurs later, just on those days when I drank Duphaston.

Duphaston suppressed my ovulation all this time,

that’s why I had anovulatory cycles all the time, and I simply couldn’t physically get pregnant...

We were shocked by what we heard. We were horrified by the incompetence of the doctor who incorrectly prescribed the drug to me, although he knew about my unstable cycle.

Now that this whole nightmare is behind me, I am 8 months pregnant, we have finally found a wonderful doctor who we really like. I hope that all the women who were incorrectly prescribed Duphaston or other drugs did not suffer too much from this and in the end everything worked out for them and they became happy mothers.

Good luck, and beware of incompetent doctors!

Source: https://zen.yandex.ru/media/acush/diufaston-i-beremennost-istoriia-pacientki-5af2f8931410c3e1e4bdafb4

When can a young woman be prescribed Duphaston?

The main indication for prescribing this medication during pregnancy planning is a deficiency of progesterone in a woman’s blood. It is the lack of this hormone that can lead to some problems that affect a woman’s ability to become a mother.

Indications for the use of Duphaston when planning a baby:

• lack of pregnancy hormone in the second phase of the menstrual cycle:
• inflammatory diseases of the mucous walls of the uterus - endometritis;
• normalization and activation of hormonal levels before implantation of a fertilized egg using in vitro fertilization;
• uterine bleeding other than menstruation;
• Irregular menstrual cycle.

Duphaston can also be used during pregnancy in case of threatened miscarriage or premature birth.

Video: progesterone and gestation

On the Internet you can find an “Open Letter to Colleagues”, allegedly signed by medical professors Krasnopolsky V.I. and Sidelnikov V.M., but we were unable to confirm its authenticity:

<…> The safety of Duphaston(r) has been confirmed by our clinical experience. In the department of therapy and prevention of miscarriage of the Federal State Institution NTsAG and P "Rosmedtekhnologiya", at the Moniiag Ministry of Health of the Russian Federation, at the RUDN University at the Department of Obstetrics and Gynecology, we widely use Duphaston(r) in everyday practice and see excellent results in the treatment of miscarriage. Therefore, we can say with confidence that today Duphaston(r) is the gestagen of choice in patients with both obstetric and gynecological pathologies caused by progesterone deficiency. In addition to the gestagenic effect, Duphaston(r) is an immunomodulator. Numerous studies around the world have shown that under the influence of Duphaston, immunocompetent cells produce progesterone-induced blocking factor, which, by acting on immune cells in the endometrium, helps normalize the endometrial-embryo immune relationship and promotes the release of a large number of growth factors and angiogenesis for the physiological development of pregnancy. Otherwise, activation of lymphokine-activated killer cells occurs with an increase in the production of pro-inflammatory cytokines and activation of local thrombophilia, which leads to chorionic detachments, the formation of retrochorial hematomas and the development of placental insufficiency if pregnancy is not terminated. Early pregnancy losses in most cases are immune-related, so the use of Duphaston is not only justified, but an extremely necessary component in the treatment of habitual pregnancy loss. Dear colleagues, of course, the choice of one drug or another is a personal decision for each doctor. And we are confident that regardless of the situation on the pharmaceutical market, you will be helped by real knowledge, accurate and verified information, common sense and a sincere desire to act solely in the interests of patients! <…>

prof. Krasnopolsky V.I., prof. Sidelnikov V. M.

https://forums.rusmedserv.com/showthread.php?t=54078

At the same forum, doctors share their personal thoughts on the above letter and on the prescription of Duphaston:

Pure Tide! The comrades who signed up should be filmed in the video and shown in advertising screensavers.

DrTodua

https://forums.rusmedserv.com/showthread.php?t=54078&page=2

1. Is it possible to determine the lack of progesterone using the graphs? Indirectly, yes, but there are more accurate research methods (for example, determining its concentration in the blood in the second phase of the cycle) 2. Is it possible to plan a pregnancy while taking Duphaston? Isn't it harmful? It's possible, it's not harmful. Although there must be indications for taking it. 3. Or maybe it’s not the hormones, but the patency of the tubes? I have the same suspicions.

B. Kamenetsky, gynecologist-reproductologist

Read also:  Why a child does not speak at 2, 3, 4 years, 5.6 years. Causes of absence and delay of speech in children.

https://forums.rusmedserv.com/showthread.php?t=63052

The principle of action of the drug Duphaston

In this case, the woman is prescribed hormonal support. The drug of choice is Duphaston. It is based on dydrogesterone, a synthetic analogue of a natural hormone. How it works: entering the blood after absorption in the gastrointestinal tract, the Duphaston molecule binds to specific proteins and acts directly on the uterine receptors. Smooth muscle relaxation occurs and hypertonicity disappears, thus maintaining and progressing pregnancy.

Read: Fetal development at 13 weeks of pregnancy - a third of the way has been completed

Before prescribing the medication, it is necessary to determine the level of progesterone in the blood. The analysis is performed either on days 21-23 of the cycle, if the patient is planning a pregnancy, or immediately after pregnancy is established.

Contraindications and possible side effects

Despite the fact that Duphaston consists, as it may seem at first glance, of hormones familiar to the female body, it is still not recommended for some categories of expectant mothers to take it in order to avoid complications and unpleasant consequences.

Contraindications to the use of the drug:

• hypersensitivity to the constituent components of the drug;
• bleeding from the vagina of unknown origin;
• Dabin-Johnson syndrome and Rotor syndrome, which are characterized as hereditary genetic diseases similar in symptoms to jaundice;
• breastfeeding period.

Side effects as a result of using Duphaston are very rare. The main reasons for their occurrence: non-compliance with the dosage and a tendency to allergic reactions.

Side effects:

• itching, burning and redness of the skin;
• pain in the peritoneum;
• vaginal bleeding other than menstrual bleeding;
• headache, weakness and drowsiness.

Some experts believe that taking hormonal drugs during pregnancy is one of the main reasons for the birth of premature, low-birth-weight babies. Moreover, this can cause placental insufficiency and fetal hypoxia.

If the above symptoms appear, you should stop taking this medication and consult a doctor. Treatment of side effects is symptomatic, since a special neutralizing medication that can “eliminate” these consequences has not been identified.

Taking Duphaston does not in any way affect the duration of the menstrual cycle, as well as the abundance of menstrual flow.

Why is Duphaston prescribed during pregnancy?

In the first half of pregnancy, the formation and formation of all organs and systems of the unborn child, the development and formation of the placenta, occurs. If at this stage the body experiences a deficiency of the hormone, and pregnancy proceeds against the background of a threat, then the consequences will not be long in coming:

• threatened or incipient miscarriage;
• complete abortion;
• as the process progresses, long-term consequences occur: disruption of the functioning of the placenta, which occurs due to vascular spasm, oxygen starvation of tissues, and as a consequence late gestosis, uteroplacental insufficiency, disruption of uteroplacental blood flow, intrauterine growth retardation, fetal malnutrition.

Therefore, the doctor prescribes an additional dose of Duphaston. There are different schemes for using the drug, it all depends on the specific reason.

If this is a threatened miscarriage in a primigravida woman without a burdened obstetric-gynecological history, then prescribe 2 tablets (10 mg) 3 times a day until all symptoms disappear completely, with gradual withdrawal of the drug by 18–20 weeks.

If this is an incipient miscarriage, then I prescribe 40 mg (4 tablets) at a time, and then take 10 mg every 8 hours. Treatment continues until bleeding stops, followed by gradual withdrawal of the drug.

If this is recurrent miscarriage, infertility associated with insufficiency of the luteal phase of the cycle, then Duphaston is prescribed at the planning stage and its dose is selected individually. Here you need to understand that termination of pregnancy and infertility can be associated with other reasons: an infectious process, genetic abnormalities, so taking a hormonal drug is not always advisable.

Another niche for using the drug is IVF programs. In this case, Duphaston is prescribed at the stage of superovulation stimulation, and after embryo transfer. Considering that not very healthy women resort to assisted reproductive technologies, it is impossible to do without it.

Duphaston can be taken for a long time. The drug has no side effects, except for individual intolerance. Considering the fact that the drug molecule is as close as possible to the natural original, it is characterized by high bioavailability.

If we talk about the stage of pre-conception preparation, then it is prescribed for at least 4-6 months. During pregnancy, it can be taken up to 20 weeks, and the decision on longer use is made only by the doctor and with the consent of the patient. This is necessary because the instructions for the drug do not indicate its use beyond 20 weeks of pregnancy.

The maximum long-term use can be up to 34 weeks, since further use of the medicine does not make sense. The drug does not have a negative effect on the developing fetus.

The effectiveness of the drug in case of multiple pregnancy has not been proven. However, it is still used. This is due to the fact that twins are obtained more often in IVF protocols, where Duphaston cannot be avoided. But in the event of a threatened miscarriage, taking the drug does not increase the chances of maintaining the pregnancy.

Read: Why and how to identify an ectopic pregnancy before complications

During pregnancy, Duphaston should not be discontinued on its own, especially when prescribed for the treatment of threatened abortion. In this case, all symptoms may return with a vengeance, and repeated therapy may be ineffective.

Do not panic if for some reason you miss taking your medication. It is worth taking the required dose as soon as you remember. But there is no need to double subsequent doses of Duphaston.

The obstetrician-gynecologist decides when to start gradually reducing the dose of the medication. To do this, you need to be sure that stopping Duphaston will not lead to pregnancy loss. As a rule, it is reduced by one tablet per week either to the minimum dose or until the drug is completely discontinued. If, while reducing the dosage, pain in the lower abdomen or spotting appears again, then they return to the original doses of Duphaston, and its discontinuation is postponed for a long time.

Rules for taking medications when planning pregnancy

The use of Duphaston during pregnancy planning should only occur under the strict supervision of a physician. Taking it on your own can cause a reverse therapeutic effect, which occurs due to an excess of the pregnancy hormone . In this case, the drug begins to act according to the scheme of contraceptive drugs. Moreover, not only progesterone deficiency is the cause of infertility, therefore, before starting a treatment course, a young couple must undergo a medical examination to exclude all possible causes of the problem.

If it is impossible to conceive a baby due to low progesterone levels, doctors prescribe a course of Duphaston . But it is important to note that it should be taken strictly depending on the phases of the menstrual cycle, starting from the day of ovulation - the moment when the egg is released from the ovary. Thus, the drug must be taken from days 16 to 26 of the cycle. It is usually prescribed for a course of three months, but if conception has not occurred during this period, treatment can be continued for up to six months.

To achieve pregnancy, progesterone must be taken after ovulation.

Typically, Duphaston tablets are taken twice a day, regardless of meals, with plenty of liquid. But the exact treatment regimen must be prescribed by a doctor.

If the expectant mother is lucky enough to become pregnant, this does not mean that it is necessary to suddenly stop taking this drug. The course of treatment usually continues until the end of the 12th week of pregnancy, when the placenta takes over the functions of hormone production. Sometimes therapeutic treatment can last the entire 20 weeks of pregnancy.

Refusal from this hormonal drug occurs gradually, every day it is necessary to reduce the dosage, which is within the competence of the attending physician. Abruptly stopping the medication may cause miscarriage or premature birth.

Using Duphaston together with other medications

There were no negative consequences from the parallel use of Duphaston with other drugs. But it is worth noting that inducers of microsomal liver enzymes, such as Phenobarbital, Difenin, can accelerate the metabolism of Duphaston and weaken its effect.

Duphaston is often prescribed as part of complex therapy with other medications. For example, it can be taken in combination with Metipred when the concentration of the male hormone testosterone is too high, and progesterone, on the contrary, is insufficient. The simultaneous use of these drugs allows you to normalize hormonal levels.

Metypred helps reduce testosterone in a woman’s blood if she is unable to conceive

Very often, in the treatment of infertility, a drug tandem such as Divigel and Duphaston can be encountered. This is explained by the fact that for successful conception, the balance of the hormones progesterone and estrogen is also important. Divigel normalizes the level of estrogen, and Duphaston, as already mentioned, normalizes progesterone.

Gel Divigel is used vaginally to normalize estrogen levels

Functions of progesterone

Progesterone has several functions in the body. It causes the endometrium to mature, normalizing the menstrual cycle and preparing the site for implantation of a fertilized egg. The hormone stimulates changes in the mammary glands, preparing them for lactation.

In the first phase of the menstrual cycle, estrogen works, which promotes the growth of the endometrium; progesterone levels at this moment are low. Shortly before ovulation, progesterone levels rise and reach their peak immediately after ovulation. As already mentioned, progesterone leads to the maturation of the uterine lining. Then, throughout the entire second phase of the menstrual cycle, a fairly high level of the hormone is maintained. This occurs due to the work of the corpus luteum, a structure that appears in the ovary after ovulation has occurred.

If pregnancy does not occur, the hormone level drops and menstruation occurs. If fertilization of the egg occurs with subsequent implantation, the hormone levels do not decrease. There is such a concept as the “implantation window” - this is the coincidence of the presence of a fertilized egg in the uterine cavity and the mature endometrium. If one of these processes is delayed, then pregnancy does not develop. This is also the concern of progesterone, so that by the time the egg descends into the uterine cavity, and this process takes up to 5 days, the mucous membrane of the uterine cavity is ready to receive it.

If the level of progesterone in the blood is below the permissible norm, then pregnancy may not occur or may occur against the background of a threat of miscarriage.

What medications can be used instead of Duphaston

Thanks to the development of modern pharmaceuticals, a considerable number of hormonal drugs have been developed that allow a young woman to feel the joy of motherhood. But all drugs can be taken only as prescribed by a doctor, as they have a decent list of contraindications. It is prohibited to replace one drug with another based on your own desires.

Duphaston does not have complete structural analogues, but there are medications that have the same therapeutic effect:

• Utrozhestan;
• Iprozhin;
• Prajeesan;
• Crinon.

Tables: generics Duphaston - progesterone preparations

Photo gallery: functional generics of Duphaston

Utrozhestan is one of the best analogues of Duphaston

Iprozhin is not recommended in the second and third trimesters of pregnancy

Crinon gel is applied to the vaginal walls using a special applicator

The use of Prajisan is permissible only in the first three months of pregnancy

Which is better: Duphaston or Utrozhestan?

Duphaston and Utrozhestan are similar hormonal drugs that are equally successfully used when planning pregnancy and during the first trimester. Both of these drugs are “substitutes” for the natural hormone of the female body - progesterone. But at the same time, they have a number of differences, which play an important role in their purpose. It is worth noting that only a gynecologist can choose the most suitable and effective medicine; you should not do this yourself.

Table: comparison of Duphaston and Utrozhestan

Indications for prescribing the drug

Hormonal support has been used in the practice of obstetricians and gynecologists for a long time. One of these drugs is Duphaston. Enough clinical studies have been conducted both in the USA and Europe, as well as in Russia, which have proven the safety of taking this drug during pregnancy.

Its structure is as close as possible to natural progesterone. The history of prescribing the drug goes back decades. During this time, no truly serious side effects were recorded during the administration, either in the mother or in the fetus.

There are certain indications for prescribing Duphaston. All these conditions have one thing in common – low levels of this hormone.

Indications:

• insufficiency of the luteal phase of the cycle;
• premenstrual syndrome;
• endometrioid disease;
• menstrual irregularities;
• dysfunctional uterine bleeding;
• amenorrhea;
• threatened miscarriage;
• recurrent miscarriage;
• hormone replacement therapy during menopause.

The most important drug?

Progestron is precisely the hormone without which continuation of life is impossible. This is not just an active substance that has a beneficial effect on pregnancy. Progesterone is even called the matrix of all other hormones, which once again emphasizes its importance.

Why is Duphaston so valuable? Everything is very simple. The active substance in its composition is dydrogesterone - a progestogen, which is a synthetic analogue of human progesterone. Therefore, Duphaston is the most frequently prescribed pharmaceutical drug when planning pregnancy. It is well absorbed, does not accumulate and is completely eliminated from the body after three days. And what is important, the instructions for its use state that Duphaston does not affect metabolism and does not cause masculinization - the appearance of male-type symptoms.

Progestogen drugs help a woman restore normal progesterone levels, regulate menstrual cycles, which means they can be used to become pregnant. However, a sane person should understand that any medication, especially a hormonal one, cannot be prescribed thoughtlessly, without consulting a doctor. In addition, Duphaston dosage regimens vary depending on the pathology and the expected effect.

How to drink Duphaston for infertility

Photo: How to drink Duphaston for infertility

If you do not know how to take Duphaston for infertility, consult your doctor.

In most cases, it is used for six months according to an individual treatment regimen (dosage, frequency of use). On average, the daily dose is 10 mg. Apply once a day.

Duphaston begins to be taken after ovulation has occurred and continues to be used until a new menstrual cycle begins. If the long-awaited conception occurs, the course of treatment is continued for several more months to eliminate the risk of miscarriage.

In most cases, Duphaston, used for infertility, has a positive effect in terms of pregnancy. If this does not happen within a year after regularly and correctly taking the product, there is no need to despair. Modern medical technologies have many methods for treating patients with hormonal imbalance. You must not miss your chance and go to the doctor again for additional examination.

What you need to know about Duphaston and its analogues

In our pharmacy network you can find only two pharmaceuticals containing progestogens. These are Duphaston and Utrozhestan. When planning a long-awaited pregnancy, the active substance (yam extract) of these medications helps prepare the reproductive system for conceiving and bearing a child. In the early stages of pregnancy, they reduce uterine hypertonicity, if there really is one, although in most cases this is another reason for horror stories.

The prescription of these drugs for truly proven progesterone deficiency is justified, but in other cases, take the pills or refuse - decide for yourself. However, you should know that stopping Duphaston when planning will not have the same consequences as stopping taking the pills during pregnancy.

The body of a woman taking synthetic progestogens gets used to receiving the required amount of active substances from the outside. Therefore, the pregnancy hormone - first luteal, and then placental progesterone - is poorly synthesized, because its deficiency will still be replenished.

As a consequence of this, abrupt refusal of the drug will lead to a sudden deficiency of progesterone, uterine contractions and miscarriage. To prevent undesirable withdrawal effects, you should stop taking Duphaston or Utrozhestan in stages, allowing the body to gradually independently produce the required amount of such an important hormone.